Natural killer (NK) cells are a group of innate white blood cell with cytolytic activity against virus-infected cells and physiologically stressed cells like tumor cells. It acts as the frontliner of our immune system to approach the abnormal cells at first. About 10 – 15% of peripheral blood mononuclear cells (PBMC) are consist of this NK cell.
The name ‘natural killer’ derived from the ability of NK cells that target abnormal cells without the need for prior activations due to the absence of specific cell surface receptors on it.
This characteristic of NK cells allows it to be widely applied in various therapies including immunotherapy to fight against cancer and certain viral diseases.
Are these sign and symptoms sound familiar to you?
Measurement on NK activity level
The activity of our NK cells is a conventional parameter that can now be quantified through 1 ml of blood sample. This measurement provides reliable results in assessing our immune level by measuring the cytokine concentration/level of IFN-ɣ released by activated NK cells upon stimulations.
This test employed the principle of antigen-antibody reaction (Sandwich ELISA) that highly specific in detecting and measuring only the IFN-ɣ level by activated NK cell.
Measurement on NK activity level is useful as complementary diagnostic tool to provide early signs of disease or a screening of disease state.
A promising anti-cancer strategy which flexible to be combined with other conventional cancer therapies such as chemotherapy, radiotherapy, and surgery.
NK Immunotherapy enriches and enhances your own defend system against the enemies.
A series of microscopic picture on HIV-1-infected cell killing by NK cells. These pictures were taken every 5 minutes and lead to the dying of cells.
Green: HIV-1 infected cell
Round, arrow pointed: NK cell
Blue dye: Dying cell